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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

4.6K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.6K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Related Experiment Video

Updated: Oct 8, 2025

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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Cytomorphological study of thyroid carcinoma.

Iuliana Mohorea1,2, Dana Terzea3, Daniela Mihalache2,4

  • 1Department of Pathology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Experimental and Therapeutic Medicine
|December 31, 2021
PubMed
Summary

Thyroid tumors are common, with aggressive variants requiring accurate diagnosis. Ultrasound-guided fine-needle aspiration cytology, combined with histopathology, is crucial for identifying aggressive thyroid cancer and improving patient management.

Keywords:
cytopuncture of the thyroidfine-needle aspirationhistopathologythyroid carcinomathyroid cytomorphologythyroid tumors

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Area of Science:

  • Endocrinology
  • Oncology
  • Pathology

Background:

  • Thyroid neoplasms are the most common endocrine tumors, with increasing incidence due to advanced diagnostics.
  • While most thyroid tumors have a favorable prognosis, aggressive variants present significant clinical challenges.

Purpose of the Study:

  • To correlate ultrasound-guided fine-needle aspiration cytology (FNAC) findings with histopathological examination in thyroid tumors.
  • To highlight the importance of FNAC and histopathology in identifying aggressive thyroid carcinoma variants, particularly poorly differentiated types.

Main Methods:

  • Retrospective analysis of thyroid tumor cases from surgical, oncology, and forensic pathology departments.
  • Comprehensive histopathological diagnosis for all selected cases to ensure accuracy.

Main Results:

  • Ultrasound-guided FNAC, when correlated with histopathology, is a reliable method for differential diagnosis of thyroid tumors.
  • This combined approach is essential for recognizing aggressive papillary carcinoma variants, impacting patient prognosis and treatment.

Conclusions:

  • Accurate histopathological examination following FNAC is critical for definitive diagnosis and classification of thyroid tumors.
  • Early recognition of aggressive thyroid cancer subtypes through cytological and histological correlation is vital for effective clinical management and improved patient outcomes.