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Pharmaceutical Lozenges: Recent Trends and Developments with an Update on Research and Patents
Mangesh Pradeep Kulkarni1, Arun Sharma1, Sagar Tanwar1
1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411,-India.
Recent Advances in Drug Delivery and Formulation
|December 31, 2021
Summary
Medicated lozenges (LZs) offer a palatable oral drug delivery system, benefiting patients with swallowing difficulties and enhancing drug bioavailability. This review explores lozenge formulation, manufacturing, and applications.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Oral dosage forms are preferred for their convenience and ease of administration.
- Lozenges (LZs) are a significant oral dosage form with unique pharmaceutical applications.
- LZs provide benefits for pediatric, geriatric, and gastrointestinal patients, addressing issues like dysphagia.
Purpose of the Study:
- To provide a comprehensive review of medicated lozenges (LZs) as a drug delivery system.
- To cover various aspects including formulation, manufacturing, and evaluation of LZs.
- To compile existing research and discuss marketed products and patents related to LZs.
Main Methods:
- Literature review of pharmaceutical research on lozenges.
- Analysis of formulation strategies and manufacturing techniques for LZs.
- Examination of evaluation parameters, marketed products, and patents.
Main Results:
- Lozenges offer enhanced drug retention time in the oral cavity, improving bioavailability.
- Medicated LZs provide an effective route for drug administration, bypassing the first-pass effect.
- LZs are versatile for treating buccal, upper gastrointestinal disorders, and for patients with swallowing difficulties.
Conclusions:
- Lozenges represent a valuable and versatile oral drug delivery system.
- Further research and development in lozenge technology can expand their therapeutic applications.
- Medicated lozenges are crucial for improving patient compliance and therapeutic outcomes.
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