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Repeatability and robustness of MP-GRASP T1 mapping.

Zhitao Li1, Xiang Xu2, Yang Yang2

  • 1Department of Radiology, Stanford University, Palo Alto, California, USA.

Magnetic Resonance in Medicine
|December 31, 2021
PubMed
Summary

Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) MRI offers repeatable and robust T1 mapping. This fast 3D technique maintains accuracy despite variations in imaging parameters, making it reliable for phantom and brain studies.

Keywords:
GRASP MRIGolden-angleLook-LockerMP-GRASPT1 mappingrepeatability

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Area of Science:

  • Magnetic Resonance Imaging
  • Quantitative MRI
  • Biomedical Engineering

Background:

  • Accurate T1 mapping is crucial for various MRI applications, including tissue characterization and disease monitoring.
  • Traditional T1 mapping methods can be time-consuming, limiting their clinical utility.
  • Developing fast and robust T1 mapping techniques is essential for improving imaging efficiency and reliability.

Purpose of the Study:

  • To evaluate the repeatability and robustness of fast 3D T1 mapping using Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) MRI.
  • To assess the impact of variations in imaging parameters, such as flip angle and spatial resolution, on MP-GRASP T1 mapping accuracy.
  • To validate MP-GRASP T1 mapping performance in both phantom and in-vivo brain studies.

Main Methods:

  • MP-GRASP T1 mapping was assessed for B1 inhomogeneity using a phantom.
  • Repeatability was compared between MP-GRASP and inversion recovery-based spin-echo (IR-SE) over multiple scans.
  • Longitudinal T1 variation was evaluated using MP-GRASP with varied parameters in phantoms and brain scans.
  • MP-GRASP accuracy was validated against IR-SE using linear correlation and Lin's concordance correlation coefficient (CCC).

Main Results:

  • MP-GRASP demonstrated good robustness to B1 inhomogeneity with <1% intra-slice variability.
  • Longitudinal variability of T1 estimation was low in both phantom (<2.5%) and brain (<2%) studies.
  • MP-GRASP T1 values showed high accuracy compared to IR-SE (R² = 0.997, CCC = 0.996).

Conclusions:

  • MP-GRASP provides excellent repeatability for T1 estimation over time.
  • The technique is robust to variations in key imaging parameters.
  • MP-GRASP is a reliable method for fast and accurate 3D T1 mapping in clinical and research settings.