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B cells secrete GABA, which provokes a pro-tumor immune microenvironment

Mara Gilardi1, Monika Ramos1, Daniel Hollern1

  • 1Salk Institute for Biological Studies, La Jolla, CA, USA; Salk Cancer Center, La Jolla, CA, USA; NOMIS Center for Immunobiology and Microbial Pathogenesis, La Jolla, CA, USA.

Cancer Cell
|December 31, 2021
PubMed

In a recent publication in Nature, Zhang et al. report that foreign antigen stimulation elicits bountiful changes in lymphatic metabolite production-changes that include B cells secreting GABA, which reprograms macrophages and limits T cell cytotoxicity. This signifies a new mechanism by which B cells regulate immune suppression and facilitate tumor progression.

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