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Reintroducing serum FSH measurement during ovarian stimulation for ART
Barbara Lawrenz1, Laura Melado2, Shieryl Digma2
1IVF Department, ART Fertility Clinics, Abu Dhabi, UAE; Women's University Hospital Tuebingen, Tuebingen, Germany.
Reproductive Biomedicine Online
|January 2, 2022
Summary
Higher follicle-stimulating hormone (FSH) levels during ovarian stimulation for in vitro fertilization (IVF) correlate with increased progesterone production. This suggests a link between FSH and progesterone, independent of ovarian response outcomes.
Area of Science:
- Reproductive Endocrinology
- In Vitro Fertilization (IVF)
Background:
- Ovarian stimulation protocols for IVF aim to optimize follicle development.
- The role of systemic follicle-stimulating hormone (FSH) concentrations on progesterone levels during stimulation requires further elucidation.
Purpose of the Study:
- To investigate the impact of systemic FSH concentrations during ovarian stimulation on systemic progesterone levels in the late follicular phase of IVF cycles.
Main Methods:
- A post-hoc analysis of a randomized controlled trial (RCT) involving 105 patients undergoing ovarian stimulation with a gonadotrophin-releasing hormone (GnRH) antagonist protocol.
- Patients were stratified based on median day of trigger (DoT) FSH concentrations.
- Systemic FSH and progesterone levels were measured, along with total gonadotrophin dosage.
Main Results:
- Higher systemic FSH concentrations on the day of trigger (DoT) were associated with significantly higher progesterone levels on DoT and higher progesterone per follicle.
- Systemic DoT FSH concentration positively correlated with DoT progesterone concentration and progesterone per follicle.
- No significant correlation was found between systemic DoT FSH concentration and the number of retrieved oocytes.
Conclusions:
- Systemic FSH concentrations during ovarian stimulation appear to augment progesterone production.
- Ovarian response, in terms of oocyte yield, seems independent of systemic FSH concentrations on the day of trigger.
Keywords:
Oocyte yieldOvarian stimulationProgesteroneStimulation monitoringSystemic FSH concentrationsMore Related Videos
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