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Updated: Oct 8, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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CARDIOVASCULAR DISEASES AND ANDROGEN DEPRIVATION THERAPY.
11Department of Cardiology, Sestre milosrdnice University Hospital Center; 2Faculty of Dental Medicine and Health, University of Osijek; 3Faculty of Medicine, University of Rijeka; 4Faculty of Medicine, University of Osijek.
Acta Clinica Croatica
|January 3, 2022
Summary
Cardiovascular diseases are the primary cause of death in prostate cancer patients. Androgen deprivation therapy (ADT) significantly harms heart health, necessitating integrated cardiovascular care for prostate cancer survivors.
Area of Science:
- Oncology
- Cardiology
- Endocrinology
Background:
- Cardiovascular diseases (CVD) are the leading cause of mortality in prostate cancer patients.
- Androgen deprivation therapy (ADT) is a standard prostate cancer treatment.
- ADT adversely impacts cardiovascular health through metabolic and body composition changes.
Purpose of the Study:
- To highlight the significant cardiovascular risks associated with prostate cancer and its treatments.
- To emphasize the detrimental effects of androgen deprivation therapy (ADT) on cardiovascular health.
- To advocate for the integration of cardiovascular disease prevention and management into standard prostate cancer care.
Main Methods:
- Review of existing literature on prostate cancer, androgen deprivation therapy, and cardiovascular outcomes.
- Analysis of the mechanisms by which ADT affects cardiovascular health.
- Synthesis of evidence regarding the prevalence of cardiovascular diseases in prostate cancer survivors.
Main Results:
- Prostate cancer patients face elevated risks of coronary artery disease, stroke, myocardial infarction, and cardiovascular mortality.
- ADT contributes to metabolic syndrome, insulin resistance, obesity, and atherosclerosis.
- Prostate cancer survivors exhibit a higher prevalence of cardiovascular morbidities.
Conclusions:
- Cardiovascular disease prevention and management must be a standard component of care for prostate cancer patients.
- Addressing ADT's cardiovascular side effects is crucial for improving outcomes in prostate cancer survivors.
- Multidisciplinary care integrating oncology and cardiology is essential.
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