18KHT01, a Potent Anti-Obesity Polyherbal Formulation

Area of Science:

• Metabolic disorders
• Pharmacology
• Natural product research

Background:

• Obesity is a critical metabolic disorder with limited safe and effective treatments.
• There is an urgent need for novel therapeutic strategies to manage obesity.

Purpose of the Study:

• To develop and evaluate a novel, safe, and effective polyherbal formulation (18KHT01) for obesity management.
• To investigate the synergistic antioxidant, anti-adipogenic, and anti-obesity activities of 18KHT01.

Main Methods:

• A polyherbal formulation (18KHT01) was created using Quercus acutissima, Camellia sinensis, Geranium thunbergii, and Citrus limon.
• In vitro and in vivo studies were conducted to assess antioxidant, anti-adipogenic, and anti-obesity effects in diet-induced obese mice.
• Molecular analysis targeted key adipogenic factors (PPARγ, C/EBPα, etc.).

Main Results:

• 18KHT01 exhibited strong synergistic antioxidant and anti-adipogenic activities in vitro.
• The formulation significantly downregulated key adipogenic factors.
• In vivo, 18KHT01 reduced body weight, improved lipid profiles, alleviated insulin resistance, and decreased fat deposition in liver and adipose tissue.
• Synergy evaluation confirmed improved efficacy and reduced toxicity of ingredients.

Conclusions:

• The polyherbal formulation 18KHT01 is a safe and potent herbal therapy for obesity management.
• 18KHT01 demonstrates significant synergistic effects, offering a promising approach to combat obesity.