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LCMD: Lung Cancer Metabolome Database.

Wei-Sheng Wu1, Hsin-Yi Wu2, Pin-Hsuan Wang3

  • 1Department of Electrical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.

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|January 3, 2022
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Summary
This summary is machine-generated.

Lung cancer research urgently needs better biomarkers. The Lung Cancer Metabolome Database (LCMD) is the first resource to compile 2013 lung cancer metabolites from 65 studies, aiding biomarker discovery.

Keywords:
BiomarkerDatabaseHMDB, Human Metabolome DatabaseLCMD, Lung Cancer Metabolome DatabaseLung cancerMass spectrometryMetaboliteMetabolomeMetabolomicsNSCLC, Non-Small-Cell Lung CarcinomaVIP, Variable Importance in Projection

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Area of Science:

  • Biochemistry
  • Oncology
  • Bioinformatics

Background:

  • Lung cancer is a leading cause of cancer death globally, with a low 5-year survival rate.
  • Current diagnostic biomarkers for lung cancer lack sufficient accuracy in clinical settings.
  • Metabolomics offers a promising avenue for discovering novel lung cancer biomarkers.

Purpose of the Study:

  • To construct and introduce the Lung Cancer Metabolome Database (LCMD), the first comprehensive resource for lung cancer-related metabolites.
  • To provide researchers with a centralized platform for accessing and analyzing metabolomic data in lung cancer.
  • To facilitate the discovery of new biomarkers for lung cancer diagnosis and prognosis.

Main Methods:

  • Compilation of 2013 lung cancer-related metabolites from 65 mass spectrometry-based metabolomics studies.
  • Development of an online database (LCMD) with user-friendly browsing and filtering functionalities.
  • Inclusion of detailed information for each metabolite and study, including fold change, statistical significance, and methodology.

Main Results:

  • The LCMD successfully integrates data from numerous lung cancer metabolomics studies.
  • The database allows exploration of metabolites and studies through various search filters.
  • Each entry provides comprehensive data, including fold change, p-values, and study specifics.

Conclusions:

  • The LCMD is the first database to consolidate information on lung cancer-related metabolites.
  • This resource is expected to significantly advance lung cancer biomarker discovery.
  • The LCMD aims to accelerate research into the pathogenic mechanisms and diagnostic tools for lung cancer.