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Metal-Organic Frameworks for Bioimaging: Strategies and Challenges
Yanfei Liu1, Ting Jiang1, Zhenbao Liu2,3
1Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan Province, P. R. China.
Nanotheranostics
|January 3, 2022
Summary
Metal-organic frameworks (MOFs) show great potential for biomedical applications due to their unique properties. This review covers MOF synthesis, characterization, and their use in advanced bioimaging techniques.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Metal-organic frameworks (MOFs) are advanced materials constructed from metal ions and organic linkers.
- MOFs possess high surface area, tunable pore sizes, and versatile functionalities, making them attractive for biomedical applications.
Purpose of the Study:
- To review the synthesis and characterization methods of MOFs.
- To explore the diverse bioimaging applications of MOFs, including optical, MRI, and CT imaging.
- To discuss current challenges and future prospects for MOF-based bioimaging probes.
Main Methods:
- Literature review of MOF synthesis and characterization techniques.
- Analysis of MOF applications in various bioimaging modalities.
- Discussion of bioimaging strategies and future research directions.
Main Results:
- MOFs can be synthesized and characterized using established methods.
- MOFs demonstrate significant potential as contrast agents and probes in optical bioimaging, MRI, and CT.
- Multi-modal bioimaging using MOFs offers enhanced diagnostic capabilities.
Conclusions:
- MOFs are versatile platforms for developing advanced bioimaging probes.
- Further research is needed to overcome challenges in MOF stability and targeted delivery for clinical translation.
- MOFs hold promise for revolutionizing molecular bioimaging in medicine.
