Platelet-Rich Plasma in Androgenetic Alopecia

Area of Science:

• Dermatology
• Regenerative Medicine

Background:

• Androgenetic alopecia (AGA) is a common form of hair loss.
• Platelet-rich plasma (PRP) is increasingly used as a therapeutic option for AGA.
• Standardized protocols for PRP preparation and application in AGA are lacking.

Purpose of the Study:

• To establish evidence-based recommendations for the preparation and utilization of platelet-rich plasma (PRP) in treating androgenetic alopecia (AGA).
• To provide a practical framework for clinicians based on the GRADE methodology.

Main Methods:

• A comprehensive literature search was conducted across multiple databases.
• Evidence and recommendations were graded using the GRADE framework.
• A consensus statement was developed and critically evaluated by dermatology experts.

Main Results:

• The manual double-spin method is recommended for PRP preparation in AGA.
• A minimum of 3–5 PRP sessions are advised, spaced one month apart.
• Ideal candidates are patients with Norwood Hamilton Grade II–V AGA, with a recommended PRP dose of 5–7 mL and platelet concentration of 1–1.5 million platelets/μL.

Conclusions:

• The guidelines provide a standardized approach to PRP therapy for AGA.
• PRP is recommended for AGA treatment, with specific protocols for preparation, dosage, and administration.
• Injectable platelet-rich fibrin (I-PRF) shows promise, and PRP can be an adjunct in hair transplantation.