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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Association Between Myocarditis and Mortality in COVID-19 Patients in a Large Registry

Frank H Annie1, Haytham Alkhaimy2, Aravinda Nanjundappa2

  • 1CAMC Health Education and Research Institute, Charleston Area Medical Center, Charleston, WV.

Mayo Clinic Proceedings. Innovations, Quality & Outcomes
|January 3, 2022
PubMed

Insights

Myocarditis diagnosis in patients with COVID-19 was associated with a significantly higher risk of all-cause mortality within 30 days. This registry data highlights the critical impact of myocarditis on severe acute respiratory syndrome coronavirus 2 patient outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Myocarditis is an inflammation of the heart muscle that can be caused by viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
  • Understanding the impact of myocarditis on mortality in coronavirus disease 2019 (COVID-19) patients is crucial for clinical management.

Purpose of the Study:

  • To assess the association between myocarditis diagnosis and all-cause mortality in a large cohort of patients with COVID-19.
  • To analyze registry data to determine the impact of myocarditis on mortality outcomes in COVID-19 patients.

Main Methods:

  • Utilized the TriNetX database to identify adult patients diagnosed with COVID-19 between January 20, 2020, and December 9, 2020.
  • Compared all-cause mortality between propensity-matched patients with and without a myocarditis diagnosis.
  • Included 259,352 patients with COVID-19, of whom 383 (0.2%) had a myocarditis diagnosis.

Main Results:

  • Patients with COVID-19 and myocarditis were predominantly male (59.0% vs 45.0%).
  • Propensity-matched analysis revealed a significantly higher 30-day all-cause mortality rate in patients with myocarditis (13.4%) compared to those without (4.2%) (P<0.001).
  • Kaplan-Meier survival analysis confirmed a statistically significant difference in survival at 30 days (P<0.001).

Conclusions:

  • A myocarditis diagnosis in COVID-19 patients is associated with increased all-cause mortality.
  • Further prospective research is recommended to investigate myocarditis outcomes and treatment strategies in COVID-19 patients.
Abstract

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