Related Experiment Video
Updated: Jul 1, 2026

04:53
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
10.8K
Does the Bleaching Gel Application Site Interfere With the Whitening Result? A Randomized Clinical Trial
Lmb Esteves1, T C Fagundes2, P H Dos Santos3
1Lara Maria Bueno Esteves, DDS, MS student, Department of Preventive and Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry Araçatuba, São Paulo, Brazil.
Operative Dentistry
|January 3, 2022
Summary
The location where 35% hydrogen peroxide (H2O2) bleaching gel is applied does not affect overall tooth whitening results. However, applying gel only to the cervical region increased spontaneous tooth sensitivity.
Area of Science:
- Dental Aesthetics
- Materials Science in Dentistry
Background:
- Tooth whitening is a popular cosmetic dental procedure.
- The application technique of bleaching agents may influence efficacy and patient experience.
Purpose of the Study:
- To investigate how the application site of 35% hydrogen peroxide (H2O2) bleaching gel impacts tooth color change and postoperative sensitivity.
- To compare cervical, incisal, and full facial application sites.
Main Methods:
- Thirty patients were divided into three groups based on gel application site (cervical, incisal, full facial).
- Color changes were measured using spectrophotometry (ΔE, Wid).
- Sensitivity was assessed via questionnaires and thermosensory analysis (TSA).
Main Results:
- Chromatic alteration was independent of the gel application site.
- The incisal region showed momentary color improvement, but overall results were similar across groups by treatment end.
- Spontaneous sensitivity was higher in the cervical application group.
- The full facial application group experienced less thermal sensitivity influence.
Conclusions:
- Tooth whitening efficacy is not dependent on the bleaching gel's application site.
- Concentrating 35% H2O2 gel on the cervical region increases spontaneous sensitivity.
- Thermal sensitivity can persist for up to 14 days post-treatment, with full facial application showing less impact.
Related Concept Videos
Blind Procedures
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Blinding
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.

