Should Breakthrough SARS-CoV-2 Infection Affect Our Confidence in the COVID-19 Vaccines?

Coronavirus disease 2019 (COVID-19) vaccines have shown excellent clinical efficacy and effectiveness in real-world data. Although they are regarded as a means of ending the global pandemic, some individuals become infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after immunization. This growing evidence or lack of effectiveness has led to vaccine refusal. This paper sought to help the public gain a deeper understanding of breakthrough events creating the positive perception that vaccines remain effective in ending the pandemic. Discussions vital for the general public's active participation in vaccination are expressed to create confidence or provide a potential solution to the challenge of vaccine hesitancy.