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Updated: Oct 8, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
Genome-wide association studies for growth traits in broilers
Dachang Dou1, Linyong Shen1, Jiamei Zhou1
1Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs; Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province; College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, P. R. China.
Identifying genetic markers and genes for broiler growth traits aids selection and understanding. This study found 113 quantitative trait nucleotides and key genes linked to rapid broiler growth.
Area of Science:
- Animal Genetics
- Quantitative Genetics
- Poultry Science
Background:
- Understanding the genetic basis of growth traits in broilers is crucial for improving livestock.
- Marker-assisted selection and genomic selection rely on identifying relevant genetic markers and genes.
Purpose of the Study:
- To estimate genetic parameters for eight growth traits in broilers.
- To conduct genome-wide association studies (GWAS) for these growth traits.
- To identify candidate genes associated with rapid growth in broilers.
Main Methods:
- Estimation of genetic parameters for eight growth traits.
- Genome-wide association studies (GWAS) were performed.
- Multiple methods were used to discover quantitative trait nucleotides (QTNs).
Main Results:
- Genetic parameters for eight broiler growth traits were estimated.
- A total of 113 QTNs were identified through various methods.
- Several candidate genes (e.g., ACTA1, IGF2BP1, TGFBR2) were identified as important for rapid broiler growth.
Conclusions:
- The identified markers and genes provide valuable insights into the genetic architecture of broiler growth.
- This information can enhance marker-assisted selection and genomic selection strategies in poultry breeding.
- The study contributes to a deeper understanding of the genetic foundation of growth traits in broilers.
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