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Updated: Oct 8, 2025

Reconstitution Of β-catenin Degradation In Xenopus Egg Extract
Published on: June 17, 2014
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Jiaqi Liu1, Qing Xiao1, Jiani Xiao1
1Department of Pathology, Xiangya Hospital, School of Basic Medical Sciences, Central South University, Changsha, 410013, China.
Abstract:
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.
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