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Published on: July 20, 2014
[Corrigendum] Receptor for activated C kinase 1 (RACK1) promotes the progression of OSCC via the AKT/mTOR pathway
Xuefeng Zhang1, Na Liu2, Danhua Ma1
1State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, P.R. China.
Abstract:
Subsequently to the publication of the above article, an interested reader drew to the authors' attention that Fig. 3 (showing how RACK1 silencing alters the protein expression levels of tumor malignant progress markers in OSCC in vivo) contained an overlapping data panel, such that the data were derived from the same original source where they were intending to depict the results from experiments performed under different experimental conditions and Fig. 4 (showing how RACK1 expression is positively correlated with p‑AKT in OSCC tissues and cells) contained a clearly duplicated pair of data panels. The authors were able to re‑examine their original data, and have identified the data that were intended to have been shown for these figure parts. The corrected versions of Figs. 3 and 4 are shown on the next two pages, featuring the correct data for the E‑cadherin experiments in Fig. 3B and the correct enlargement panel for the RACK1 / Moderate dysplasia experiment in Fig. 4A. The authors confirm that these inadvertent errors did not have any major impact on the conclusions reported in their paper, are grateful to the Editor of International Journal of Oncology for allowing them this opportunity to publish a Corrigendum, and apologize to the readership for any inconvenience caused. [the original article was published in International Journal of Oncology 49: 539‑548, 2016; DOI: 10.3892/ijo.2016.3562].
Insights
This corrigendum corrects errors in Figs. 3 and 4 regarding RACK1
Area of Science:
- Molecular Biology
- Oncology
- Cancer Research
Context:
- Original article investigated the role of RACK1 in oral squamous cell carcinoma (OSCC).
- Figures 3 and 4 presented data on RACK1's effect on tumor markers and its correlation with p-AKT.
- An oversight led to data presentation errors in these key figures.
Purpose:
- To correct inadvertent data presentation errors in Figures 3 and 4 of the original publication.
- To provide the accurate data for RACK1's role in OSCC progression and its association with p-AKT.
- To ensure the integrity and accuracy of the scientific record.
Summary:
- This corrigendum addresses data panel overlaps in Fig. 3 (RACK1 silencing and tumor markers) and duplication in Fig. 4 (RACK1 and p-AKT correlation).
- Corrected versions of Figs. 3 and 4 are provided, featuring accurate data for E-cadherin experiments and RACK1/moderate dysplasia.
- The authors confirm these corrections do not alter the original study's main conclusions.
Impact:
- Ensures accurate representation of RACK1's function in oral squamous cell carcinoma.
- Maintains the reliability of findings related to tumor progression markers and p-AKT signaling.
- Upholds scientific integrity by rectifying data presentation errors for the readership.
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