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Cryptococcal chorioretinitis and endophthalmitis.

D E Henderly, P E Liggett, N A Rao

Retina (Philadelphia, Pa.)

|January 1, 1987

Summary

Diagnosing endogenous fungal eye infections is challenging. Early diagnosis via vitreous biopsy and combined surgical-antifungal treatment are crucial for cryptococcal endophthalmitis.

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Area of Science:

Ophthalmology
Infectious Diseases
Mycology

Background:

Endogenous fungal endophthalmitis poses diagnostic challenges.
Intraocular inflammation unresponsive to standard therapies requires further investigation.

Observation:

A patient presented with hydrocephalus, progressing to bilateral intraocular inflammation.
Diagnosis was confirmed as cryptococcal chorioretinitis, endophthalmitis, and meningitis via vitreous biopsy and lumbar puncture.

Findings:

Systemic amphotericin monotherapy failed to resolve intraocular fungal infection.
Vitrectomy combined with intravitreal and systemic amphotericin successfully halted disease progression.

Implications:

Vitreous biopsy is valuable for diagnosing refractory intraocular inflammation.
Combined surgical and intravitreal antifungal therapy is effective for severe fungal endophthalmitis.

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