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This summary is machine-generated.

This study shows methotrexate injections effectively treated recurrent epiretinal membrane (ERM) after surgery. This offers a new option for patients with surgically resistant ERM.

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Intravitreal Injections in the Ovine Eye

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

Area of Science:

Ophthalmology
Retinal Surgery
Pharmacology

Background:

Epiretinal membrane (ERM) can cause visual impairment.
Recurrent ERM after surgery presents a treatment challenge.
Standard treatments may fail in some patients.

Observation:

A 65-year-old woman experienced recurrent epiretinal membrane (ERM) despite previous surgery.
The patient underwent revision vitrectomy and membrane peeling.
Following surgery, she received 12 weekly intravitreal methotrexate injections.

Findings:

Significant improvement in visual acuity was observed.
Marked reduction in central macular thickness occurred.
No recurrence of ERM was noted at 7 months post-treatment.

Implications:

This is the first report of methotrexate for surgically resistant recurrent ERM.
Methotrexate may be a viable treatment for refractory ERM reproliferation.
This approach could benefit patients unresponsive to conventional therapies.