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Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
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Oral leukoplakia: A clinicopathological study and malignant transformation
Serban Tovaru1, Mariana Costache2, Paula Perlea3
1Department of Oral Medicine, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Oral Diseases
|January 4, 2022
Summary
Oral leukoplakia (OL) management in Romania revealed most lesions were in smokers. Biopsy is crucial, even for clinically benign OL, due to potential malignant transformation (MT) risk.
Area of Science:
- Oral pathology
- Oncology
- Dental medicine
Background:
- Oral leukoplakia (OL) is a potentially malignant disorder.
- Understanding its clinicopathological features is vital for early cancer detection.
Purpose of the Study:
- To characterize oral leukoplakia (OL) cases in Romania.
- To assess the malignant transformation (MT) risk in OL patients.
Main Methods:
- Retrospective hospital-based study.
- Analysis of clinical charts with histopathological evaluation.
- Follow-up duration of 1-16 years.
Main Results:
- 120 patients with OL were analyzed; 59.2% were current smokers.
- Malignant transformation (MT) occurred in 9 cases (7.5%), associated with dysplasia grade (p=0.007).
- MT was more frequent in females and those with dysplastic leukoplakia.
Conclusions:
- Most OL lesions were clinically homogeneous and histologically benign.
- Biopsy is recommended for all OL, regardless of clinical appearance.
- Early detection and biopsy can mitigate MT risk.
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