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Abstract:
The immune system shows its best reactivity in the youth. Then there is a continuous slightly decrease of the reactivity. This is not caused by a loss of lymphocytes or antibody but by a shift within the distribution of regulatory cells. Therefore the portion of aberrant phenomena is increasing during lifetime. However, even in old age the immune system is still working. A concomitant increase of infections is due to the impaired resistance of anatomical structures, e.g. of the mucosa.