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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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Origin of Allergy From In Utero Exposures to the Postnatal Environment

Jessica Hui-Beckman1, Byung Eui Kim1, Donald Ym Leung2

  • 1Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA.

Allergy, Asthma & Immunology Research
|January 4, 2022
PubMed

Insights

Understanding the origins of allergy is crucial for prevention. The perinatal environment and epithelial barrier function significantly influence the development of atopic conditions in infants.

Area of Science:

  • Immunology
  • Developmental Biology
  • Environmental Health

Background:

  • Rising incidence of atopic conditions necessitates understanding allergy origins.
  • The perinatal period is critical for immune system and microbiome development.
  • Maternal exposures significantly impact fetal immune development.

Purpose of the Study:

  • To explore the origins of allergy, focusing on perinatal influences.
  • To investigate the role of epithelial barrier dysfunction in allergy development.
  • To identify factors contributing to the increasing prevalence of atopic conditions.

Main Methods:

  • Review of existing literature on perinatal environment and allergy.
  • Analysis of factors affecting epithelial barrier integrity (skin, airway, gut).
  • Consideration of genetic predispositions and maternal exposures.

Main Results:

  • Perinatal environment and maternal exposures are key determinants of fetal immune development.
  • Dysfunctional epithelial barriers allow allergen penetration, driving type 2 inflammation.
  • Both environmental factors and genetic predispositions contribute to allergy onset.

Conclusions:

  • Understanding allergy origins requires studying the perinatal environment and epithelial barrier function.
  • Comprehensive birth cohort and mechanistic studies are essential for future prevention strategies.
  • Interventions targeting the perinatal period may hold promise for allergy prevention.

Keywords:
Allergyallergensasthmacytokinesdermatitis, atopicetiologyfood allergyimmune systemmicrobiome

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