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Natural History and Influencing Factors of Chronic Urticaria in Children

Hyeon A Kim1, Myung Chul Hyun1, Bong Seok Choi2

  • 1Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, Korea.

Allergy, Asthma & Immunology Research
|January 4, 2022
PubMed

Insights

Most children with chronic urticaria (CU) have chronic spontaneous urticaria (CSU). Total immunoglobulin E (IgE) levels may predict disease duration, but no other factors reliably predict remission in pediatric CU patients.

Area of Science:

  • Pediatric Dermatology
  • Allergy and Immunology

Background:

  • Chronic urticaria (CU) significantly impacts children's quality of life.
  • Limited research exists on the natural progression of CU in pediatric populations.

Purpose of the Study:

  • To investigate the natural course of chronic urticaria in children.
  • To identify prognostic factors influencing the disease's outcome.

Main Methods:

  • A cohort of 77 children with CU was followed for at least 48 months.
  • Patients were categorized into chronic spontaneous urticaria (CSU) and other CU subtypes.
  • Remission was defined as >1 year symptom-free without treatment; remission rates and influencing factors were analyzed.

Main Results:

  • The majority of pediatric CU patients (83.1%) were diagnosed with CSU.
  • Remission rates for CU reached 70.2% by 4 years; for CSU, it was 75.0%.
  • Elevated total serum immunoglobulin E (IgE) levels showed a positive correlation with disease duration (P=0.021).

Conclusions:

  • Chronic spontaneous urticaria is the predominant subtype of CU in children.
  • No predictive indicators for spontaneous remission were identified, apart from total IgE levels.
  • The study provides reference data for the expected progression of pediatric CU.
Abstract

Keywords:
Chronic urticariachildchronic inducible urticariachronic spontaneous urticaria

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