Syringomatous hyperplasia and eccrine squamous syringometaplasia associated with benoxaprofen therapy

Two patients are described, each of whom developed multiple eruptive lesions on sun-exposed areas within days after starting benoxaprofen therapy. The lesions were 2- to 5-mm papules suggestive of syringomas, and microscopically showed squamous metaplasia of eccrine ducts and focal necrosis of eccrine keratinocytes as well as prominent eccrine hyperplasia. In both cases, the lesions resolved completely after benoxaprofen therapy was discontinued. A theoretical basis for these findings is discussed.