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Updated: Oct 7, 2025

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
Two new cytisine-type alkaloids from the seeds of Thermopsis lanceolata
Peng Zhang1,2,3, Ji-Bin Zou2,3, Qiao An2,3
1School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
Abstract:
Two new (1 and 2) cytisine-type alkaloids that were chemically inseparable isomers (present in a 1:1 ratio) were identified from the seeds of Thermopsis lanceolata R. Br. Their structures were elucidated by comprehensive spectroscopic data analysis (IR, UV, NMR, HRESIMS) and ECD calculation. Compound 1 displayed significant anti-tobacco mosaic virus (TMV) activity, while compounds 1 and 2 displayed moderate insecticidal activities against Aphis fabae with LC50 value of 43.15 and 46.47 mg/L, respectively.
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