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Updated: Oct 7, 2025
Simultaneous fMRI and Electrophysiology in the Rodent Brain
Published on: August 19, 2010
Event-recurring multiband SWIFT functional MRI with 200-ms temporal resolution during deep brain stimulation and
Ekaterina Paasonen1,2, Jaakko Paasonen1, Lauri J Lehto2
1A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Purpose:
To develop a high temporal resolution functional MRI method for tracking repeating events in the brain.
Methods:
We developed a novel functional MRI method using multiband sweep imaging with Fourier transformation (SWIFT), termed event-recurring SWIFT (EVER-SWIFT). The method is able to image similar repeating events with subsecond temporal resolution. Here, we demonstrate the use of EVER-SWIFT for detecting functional MRI responses during deep brain stimulation of the medial septal nucleus and during spontaneous isoflurane-induced burst suppression in the rat brain at 9.4 T with 200-ms temporal resolution.
Results:
The EVER-SWIFT approach showed that the shapes and time-to-peak values of the response curves to deep brain stimulation significantly differed between downstream brain regions connected to the medial septal nucleus, resembling findings obtained with traditional 2-second temporal resolution. In contrast, EVER-SWIFT allowed for detailed temporal measurement of a spontaneous isoflurane-induced bursting activity pattern, which was not achieved with traditional temporal resolution.
Conclusion:
The EVER-SWIFT technique enables subsecond 3D imaging of both stimulated and spontaneously recurring brain activities, and thus holds great potential for studying the mechanisms of neuromodulation and spontaneous brain activity.
