Two new compounds from edible mushroom Sarcomyxa edulis

Area of Science:

• Natural Product Chemistry
• Pharmacology

Background:

• The edible mushroom Sarcomyxa edulis is a source of bioactive compounds.
• Understanding the chemical constituents and biological activities of edible mushrooms is crucial for potential therapeutic applications.

Purpose of the Study:

• To isolate and characterize novel chemical compounds from Sarcomyxa edulis.
• To evaluate the anti-inflammatory potential of the isolated compounds.

Main Methods:

• Chemical investigation involving isolation and structure elucidation using HR-ESI-MS and NMR spectroscopy.
• In vitro anti-inflammatory assay using lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 macrophages.

Main Results:

• One new sterol (1) and one new β-carboline alkaloid (2) were isolated, along with nine known compounds.
• Compound 2 exhibited significant anti-inflammatory activity (IC50 = 9.88 ± 0.48 μM).
• Compound 1 showed weak anti-inflammatory activity (IC50 = 71.36 ± 5.11 μM).

Conclusions:

• Sarcomyxa edulis contains novel sterol and β-carboline alkaloid compounds.
• The isolated β-carboline alkaloid possesses notable anti-inflammatory properties, suggesting potential therapeutic value.