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A Case of Coombs-Negative Hemolytic Anemia Prompting Diagnosis of SARS-CoV-2
Thanuja Neerukonda1, Walid Moughabel1, Justin Chen1
1Internal Medicine, Brandon Regional Hospital, Brandon, USA.
Abstract:
Case reports have discussed coronavirus disease of 2019 (COVID-19) patients presenting with hemolytic anemia, specifically with a positive direct antiglobulin test. However, Coombs-negative hemolytic anemia in COVID-19 patients has been rarely reported. We present an unusual case of Coombs-negative hemolytic anemia caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which responded with evidence-based COVID-19 treatments. We demonstrate the importance of considering SARS-CoV-2 as a cause of Coombs-negative hemolytic anemia, and we illustrate how treatment of the underlying COVID-19 illness, even if it is just supportive care, will help resolve the associated hemolysis.
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