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Related Concept Videos

Nucleic Acid Structure01:25

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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The DNA Helix01:07

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Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
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DNA as a Genetic Template02:05

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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DNA Replication02:40

DNA Replication

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DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
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The Replisome03:01

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DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
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Single-Strand DNA Binding Proteins01:03

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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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Updated: Oct 7, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Recent Advances in Constructing Higher-Order DNA Structures.

Jing Wang1,2, Dong-Xia Wang1, Bo Liu1

  • 1State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular Recognition Research Centre for Analytical Sciences, College of Chemistry, Nankai University, Weijin Road, Tianjin, 300071, P. R. China.

Chemistry, an Asian Journal
|January 6, 2022
PubMed
Summary
This summary is machine-generated.

Molecular self-assembly utilizes DNA nanotechnology to create advanced nanostructures beyond simple hybridization. This review explores novel construction methods, challenges, and future directions for DNA-based materials in various applications.

Keywords:
DNA nanostructuresDNA nanotechnologyDNA-based materialshigher-orderself-assembly

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Molecular Biology

Background:

  • Molecular self-assembly is crucial for biosensors, molecular devices, catalysts, and biomaterials.
  • DNA nanotechnology leverages DNA's base pairing and biocompatibility for supramolecular structures.
  • DNA nanostructure assembly is evolving beyond hybridization to include other biochemical interactions.

Purpose of the Study:

  • To review the latest methods for constructing higher-order DNA structures.
  • To discuss current challenges in DNA nanostructure development.
  • To provide insights into future research directions in DNA nanotechnology.

Main Methods:

  • Literature review of advanced DNA nanostructure construction techniques.
  • Analysis of emerging biochemical interactions in DNA assembly.
  • Discussion of identified problems and future prospects in the field.

Main Results:

  • Summary of novel methods for creating complex DNA nanostructures.
  • Identification of key challenges hindering DNA nanostructure development.
  • Outline of promising future research avenues.

Conclusions:

  • DNA nanotechnology offers versatile platforms for advanced material design.
  • Continued innovation in assembly methods will expand DNA nanostructures' applications.
  • Addressing current challenges is key to unlocking the full potential of DNA-based materials.