Relationship of selective complement markers with schizophrenia
Abdull Jalil Mohd Asyraf1, Abd Rahim Nour El Huda1, Mohd Noor Hanisah2
1Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia.
Journal of Neuroimmunology
|January 6, 2022
Summary
Complement markers C3 and C4 were significantly higher in schizophrenia patients. These levels correlate with body mass index and C-reactive protein, suggesting potential use as peripheral biomarkers for schizophrenia.
Area of Science:
- Neuroscience
- Immunology
- Biochemistry
Background:
- Immune system dysregulation is implicated in schizophrenia.
- Previous biomarker studies for schizophrenia have yielded inconsistent results.
Purpose of the Study:
- To investigate the relationship between plasma complement markers C3 and C4 and schizophrenia.
- To explore correlations with sociodemographic and clinico-psychological factors.
Main Methods:
- Plasma levels of C3 and C4 were measured in 183 schizophrenia patients and 212 controls.
- Statistical analyses, including multivariate analyses, were performed.
Main Results:
- C3 and C4 levels were significantly elevated in schizophrenia patients compared to controls.
- Elevated C3 and C4 levels were observed in subjects with high C-reactive protein (CRP).
- C3 and C4 levels positively correlated with body mass index (BMI).
- Schizophrenia, BMI, and CRP were significant predictors of C3 and C4 levels.
Conclusions:
- Complement markers C3 and C4 show potential as peripheral biomarkers in schizophrenia.
- These findings highlight the link between immune markers, BMI, and CRP in schizophrenia.
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