Related Experiment Video
Updated: Oct 7, 2025

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery
Published on: June 2, 2022
Oral Aversion in Infants With Congenital Heart Disease: A Single-Center Retrospective Cohort Study
Stephanie A Goldstein1, Kimberly J Watkins2, Ray E Lowery3
1Division of Pediatric Critical Care, Department of Pediatrics, University of Utah, Primary Children's Hospital, Salt Lake City, UT.
Insights
Oral aversion (OA) affects nearly a quarter of neonates one year after heart surgery. Early oral feeding at discharge may reduce the risk of developing OA in infants.
Area of Science:
- Pediatric Cardiology
- Neonatal Surgery
- Feeding Disorders
Background:
- Neonates undergoing cardiac surgery face risks, including oral aversion (OA).
- Oral aversion's long-term impact beyond initial hospitalization is not well-documented.
- Understanding OA prevalence is crucial for affected infants and their families.
Purpose of the Study:
- To determine the prevalence of oral aversion (OA) at one year of age in neonates who underwent cardiopulmonary bypass (CPB) surgery.
- To identify risk factors associated with OA in this vulnerable population.
- To explore the relationship between feeding practices and OA development.
Main Methods:
- A retrospective cohort study was conducted at a single quaternary care hospital.
- 157 neonates who underwent CPB surgery between 2014 and 2017 with one-year follow-up data were analyzed.
- Feeding experts reviewed medical records to diagnose OA, with inter-rater reliability assessed.
Main Results:
- Oral aversion (OA) was present in 23.6% of patients at one year; an additional 18.5% had other feeding difficulties.
- Factors associated with OA included longer ICU stays, mechanical ventilation, nil per os days, and delayed oral feeding initiation.
- Infants with any oral intake at discharge had significantly lower odds of developing OA at one year.
Conclusions:
- Oral aversion and feeding difficulties are common sequelae in neonates post-cardiopulmonary bypass surgery.
- Delayed initiation of oral feeding appears to be a modifiable risk factor for OA.
- Interventions promoting early oral feeding may improve long-term functional outcomes for these infants.
Objectives:
Neonates undergoing cardiac surgery are at risk for oral aversion (OA). OA is not well described outside of the index hospitalization and impacts patients and families. We evaluated the prevalence of OA at 1 year old after neonatal cardiopulmonary bypass (CPB) surgery.
Design:
Retrospective cohort study.
Setting:
Single quaternary care hospital.
Subjects:
Our cohort included 157 neonates who underwent CPB surgery from 2014 to 2017 and had follow-up data available at 1 year old.
Interventions:
None.
Measurements And Main Results:
Three feeding experts reviewed the medical record to define children with OA; 30% of charts were evaluated in triplicate for validation. Neonates with and without OA were compared in univariate analysis, and risk factors for OA were explored in a limited multivariable analysis. OA was present at 1 year in 37 patients (23.6%) and other feeding difficulties were present in an additional 29 patients (18.5%). Thirty-eight patients (24.2%) had a feeding tube, including 12 (7.6%) with a gastrostomy tube. Factors associated with OA at 1 year included total ICU days, duration of mechanical ventilation, total number of nil per os days, and number of postoperative days (PODs) until oral feeding initiation (all p < 0.0001). Number of POD until oral feeding initiation remained independently associated with OA at 1 year in multivariable analysis (adjusted odds ratio, 1.08; 95% CI, 1.04-1.12; p < 0.0001). Infants with any oral intake at discharge had lower odds of OA at 1 year (0.21; 95% CI, 0.08-0.5; p = 0.0003). At hospital discharge, 132 patients (84.1%) were taking some oral feeds, and 128 patients (81.5%) received tube feeding.
Conclusions:
OA and other feeding difficulties are common at 1 year old in neonates undergoing CPB surgery. Delayed exposure to oral intake may be a modifiable risk factor for OA and efforts to improve early oral feeding could lead to better functional outcomes.
More Related Videos
08:42Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China
Published on: February 11, 2022
06:07Exploring Infant Sensitivity to Visual Language using Eye Tracking and the Preferential Looking Paradigm
Published on: May 15, 2019
Related Concept Videos
Conditioned Taste Aversion
A notable characteristic of conditioned taste aversion is that it often requires only a single...
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Stenosis III: Medical Management
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Mitral Regurgitation I: Introduction