Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosome abnormalities in peripheral T-cell lymphoma.

T Lakkala-Paranko1, K Franssila, K Lappalainen

  • 1Department of Medical Genetics, University of Helsinki, Finland.

British Journal of Haematology
|August 1, 1987
PubMed
Summary

Cytogenetic analysis of peripheral T-cell lymphomas revealed clonal chromosome abnormalities in all six patients. Trisomy 3 was specifically linked to T-zone lymphomas, aiding in diagnosis and classification.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

No evidence for microsatellite instability in acute myeloid leukemia.

Leukemia·2017
Same author

The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia.

Leukemia·2017
Same author

Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia.

Leukemia·2016
Same author

Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2.

Leukemia·2016
Same author

MicroRNA-related sequence variations in human cancers.

Human genetics·2013
Same author

Recurrent and founder mutations in the PMS2 gene.

Clinical genetics·2012

Area of Science:

  • Hematology
  • Oncology
  • Cytogenetics

Background:

  • Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoid malignancies.
  • Accurate classification of PTCLs is crucial for prognosis and treatment.
  • Cytogenetic abnormalities are known to play a role in lymphomagenesis.

Purpose of the Study:

  • To investigate the role of cytogenetic analysis in the diagnosis and classification of peripheral T-cell lymphomas.
  • To identify specific chromosomal abnormalities associated with different subtypes of PTCLs.

Main Methods:

  • Histological, immunological, and cytogenetic analysis of neoplastic lymph nodes from six PTCL patients.
  • Immunophenotyping using CD markers (CD2, CD4).
  • Karyotyping to detect clonal chromosome abnormalities.

Related Experiment Videos

Main Results:

  • All six cases were classified as PTCLs, with subtypes including T-zone lymphoma, large cell variants, and mycosis fungoides.
  • Immunologically, all cases expressed CD2 and CD4.
  • Clonal chromosome abnormalities were present in all cases, with chromosome 3 frequently involved (five patients).
  • Trisomy 3 was observed in all T-zone lymphoma cases.
  • Angioimmunoblastic lymphadenopathy (AILD) cases showed only numerical abnormalities, while others had complex structural rearrangements.
  • Recurring structural abnormalities involved 1p12/13, 1q32, 3p25, and 14q11.

Conclusions:

  • Cytogenetic analysis can assist in the diagnosis and classification of peripheral T-cell lymphomas.
  • Specific chromosomal abnormalities, such as trisomy 3 in T-zone lymphomas, may serve as diagnostic markers.
  • Integrated diagnostic approaches combining histology, immunology, and cytogenetics are valuable for PTCLs.