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Updated: Oct 7, 2025

Influence of Step-Width Manipulation on Running Biomechanics
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One small mouse step for man.

Roderick J Tan1

  • 1Department of Medicine, Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Kidney International
|January 7, 2022
PubMed
Summary
This summary is machine-generated.

Spaceflight altered kidney function in genetically engineered mice. Nuclear factor erythroid 2-related factor 2 (NFE2L2) knockout mice showed gene changes affecting vitamin D and blood pressure, impacting lipid metabolism.

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Area of Science:

  • Space biology and nephrology
  • Genetics and molecular biology

Background:

  • Kidney function changes during spaceflight are not fully understood.
  • The nuclear factor erythroid 2-related factor 2 (NFE2L2) knockout mouse is a novel model for spaceflight research.

Purpose of the Study:

  • To investigate the impact of spaceflight on kidney function using NFE2L2 knockout mice.
  • To analyze gene expression changes in the kidneys of space-flown NFE2L2 knockout and wild-type mice.

Main Methods:

  • Comparative analysis of kidney tissues from space-flown and ground-based NFE2L2 knockout and wild-type mice.
  • Gene expression profiling to identify molecular alterations.

Main Results:

  • Spaceflight induced significant gene expression changes in all studied mice.
  • Observed alterations suggest suppression of active vitamin D levels and potential increases in blood pressure.
  • NFE2L2 may play a role in regulating genes involved in lipid excretion and metabolism.

Conclusions:

  • Spaceflight significantly impacts kidney gene expression, even in genetically modified models.
  • The NFE2L2 pathway is implicated in the kidney's response to spaceflight.
  • Further research is needed to elucidate the specific mechanisms and long-term consequences.