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Distribution and Antibiotic Susceptibility Pattern of Multidrug-Resistant Bacteria and Risk Factors Among Kidney

Liying Gong1, Luwei Zhang2, Xiaoli Liu3

  • 1Department of Nephrology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.

Infection and Drug Resistance
|January 7, 2022
PubMed
Abstract

Insights

Infections are common after kidney transplants. This study identified multidrug-resistant (MDR) bacterial infection risk factors in kidney transplant recipients (KTR), finding female gender and multiple pathogens increase risk.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Microbiology

Background:

  • Infection is a major complication post-kidney transplantation (KT), impacting outcomes for kidney transplant recipients (KTR).
  • Understanding the microbiological profile and resistance patterns of pathogens is crucial for managing KTR infections.

Purpose of the Study:

  • To investigate the microbiological profile of infections in KTR.
  • To assess bacterial resistance patterns, particularly for multidrug-resistant (MDR) bacteria.
  • To identify independent risk factors for MDR bacterial infections in KTR.

Main Methods:

  • Analysis of pathogen distribution and MDR bacterial resistance rates in 866 KTR.
  • Identification of risk factors associated with MDR bacterial infections using statistical analysis.

Main Results:

  • 214 pathogen species were isolated from 119 KTR, with 110 being MDR.
  • Escherichia coli (E. coli) was the most frequent bacterial isolate.
  • Independent risk factors for MDR infection included female gender, multiple pathogen types, and a postoperative period of less than 3 months.

Conclusions:

  • Piperacillin/tazobactam (PIT) and amikacin show potential for treating extended spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) infections.
  • Rifampicin is effective against MDR Staphylococcus infections.
  • MDR bacterial infections in KTR are linked to female gender, polymicrobial infections, and early postoperative stages.
Keywords:
ESBLKTMDRkidney transplantationmultidrug-resistantpiperacillin/tazobactamrisk factor

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