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Impaired Interhemispheric Synchrony in Bronchial Asthma.
Ya-Jun Wu1, Jie Rao1, Xin Huang2
1Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People's Republic of China.
International Journal of General Medicine
|January 7, 2022
Summary
Middle-aged adults with bronchial asthma (BA) show altered brain connectivity, particularly in areas linked to the basal ganglia, visual, and sensorimotor networks. These changes may indicate neurological factors contributing to asthma pathogenesis.
Area of Science:
- Neuroscience
- Medical Imaging
- Pulmonology
Background:
- Bronchial asthma (BA) is associated with brain reorganization in hypoxic individuals.
- Interhemispheric functional connectivity alterations in BA remain largely unexplored.
Purpose of the Study:
- To investigate interhemispheric functional connectivity changes in middle-aged BA patients with hypoxia.
- Utilize voxel-mirrored homotopic connectivity (VMHC) to assess these alterations.
Main Methods:
- Resting-state magnetic resonance imaging (MRI) was performed on 31 BA patients and 30 healthy controls (HCs).
- VMHC analysis identified differences in interhemispheric functional connectivity.
- Seed-based resting-state functional connectivity (rsFC) analysis explored connectivity from altered VMHC regions.
Main Results:
- BA patients exhibited significantly lower VMHC values in the basal ganglia, thalamus, insula, cuneus, calcarine, lingual gyrus, precentral, and postcentral gyri compared to HCs.
- Increased rsFC was observed in the left insula, supramarginal gyrus, postcentral gyrus (PostCG), and inferior parietal lobule (IPL) in BA patients.
Conclusions:
- Abnormal resting-state functional connectivity in specific brain regions (basal ganglia, visual, sensorimotor networks) is evident in middle-aged BA patients.
- These connectivity changes may contribute to the neuropathogenesis of asthma.
- VMHC and FC values could serve as potential clinical indicators for asthma diagnosis and treatment.
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