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Altered Dynamic Functional Connectivity in High Myopia: Findings From Leading Eigenvector Dynamics Analysis.

Bin Wei¹, Ben-Liang Shu¹, Yuan Cheng¹

¹Department of Ophthalmology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, People's Republic of China.

Clinical Ophthalmology (Auckland, N.Z.)

|December 8, 2025

Summary

This summary is machine-generated.

High myopia is linked to altered brain connectivity, specifically reduced stability in local brain networks. These findings suggest myopia impacts broader brain function, not just vision, offering potential diagnostic insights.

Keywords:

LEiDA brain networks high myopia

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Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

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Published on: March 29, 2022

Area of Science:

Neuroscience
Ophthalmology
Brain Imaging

Background:

High myopia (HM) is a prevalent refractive error with potential neurological implications.
Understanding the impact of HM on brain functional connectivity (FC) is crucial for identifying associated neural mechanisms.

Purpose of the Study:

To investigate the effects of high myopia on dynamic brain functional connectivity using Leading Eigenvector Dynamics Analysis (LEiDA).
To explore potential neural mechanisms underlying these changes in high myopia patients.

Main Methods:

LEiDA was employed to analyze dynamic functional connectivity (DFC) in 141 participants (82 HM patients, 59 healthy controls).
Key DFC metrics including Mean Dwell Time (MDT), Transition Probability (TP), and Switching Rate (SR) were compared between groups.
Statistical analysis involved two-sample t-tests with FDR correction.

Main Results:

High myopia patients exhibited significantly shorter Mean Dwell Time (MDT) in phase-locking states 1 and 2 compared to healthy controls (p = 0.012, p = 0.011).
No significant differences were observed in Transition Probability (TP), Switching Rate (SR), or occupancy rates between the groups.

Conclusions:

High myopia is associated with altered dynamic brain connectivity, particularly affecting local network stability.
These findings suggest that HM influences broader brain networks beyond the visual system.
The results may offer insights for early diagnosis and intervention strategies for high myopia.