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Prosopagnosia01:24

Prosopagnosia

Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...

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Altered Functional Specialization and Interhemispheric Coordination in Rhegmatogenous Retinal Detachment:

Yu Ji1, Yuan-Yuan Wang2, Xiao-Rong Wu1

  • 1Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.

CNS Neuroscience & Therapeutics
|January 7, 2026
PubMed
Summary

Rhegmatogenous retinal detachment (RRD) alters brain function, impacting hemispheric specialization and interhemispheric coordination. Specific brain regions and neurotransmitter pathways are implicated, with right thalamus connectivity changes distinguishing RRD patients.

Keywords:
Allen Human Brain AtlasShapley additive explanationsautonomy indexconnectivity between functionally homotopic voxelsneurotransmitters receptorsrhegmatogenous retinal detachmentsupport vector machine

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Genetics

Background:

  • Rhegmatogenous retinal detachment (RRD) is known to cause functional brain alterations.
  • The impact of RRD on hemispheric specialization, interhemispheric coordination, gene expression, and neurotransmitter receptors remains unclear.

Purpose of the Study:

  • To investigate RRD's effects on brain hemispheric specialization and interhemispheric coordination.
  • To correlate these brain alterations with gene expression patterns and neurotransmitter receptor distributions.
  • To identify potential biomarkers for distinguishing RRD patients.

Main Methods:

  • Quantified hemispheric specialization (Autonomy Index, AI) and interhemispheric cooperation (Connectivity between Functionally Homotopic Voxels, CFH) in RRD patients.
  • Integrated gene expression data (Allen Human Brain Atlas) with neuroimaging data using transcriptome-neuroimaging spatial correlation analysis.
  • Performed enrichment and protein-protein interaction analyses for identified genes.
  • Explored spatial associations between AI/CFH abnormalities and neurotransmitter receptor distributions.
  • Utilized a support vector machine (SVM) classifier with Shapley additive explanations (SHAP) for classification and feature identification.

Main Results:

  • RRD patients showed significant alterations in AI and CFH in the frontal lobe, occipital lobe, and thalamus.
  • Associated gene sets were enriched in synaptic signaling, sensory organ development, Notch signaling, and structural neuroplasticity.
  • CFH alterations spatially correlated with serotonergic, dopaminergic, glutamatergic, and cholinergic pathways.
  • The right thalamus's CFH was the most discriminative feature for distinguishing RRD patients from healthy controls via SVM-SHAP analysis.

Conclusions:

  • RRD induces significant brain functional remodeling, affecting hemispheric specialization and interhemispheric coordination.
  • Findings provide insights into the neurobiological underpinnings of RRD.
  • This study offers a foundation for developing central intervention strategies and diagnostic imaging tools for retinal diseases.