Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 14, 2026

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
11:38

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

Multiscale Cortical Remodeling Following Abrupt Visual Deafferentation in Rhegmatogenous Retinal Detachment: Imaging

Yu Ji1, Xin Huang2,3,4, Yuan-Yuan Wang5

  • 1Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.

CNS Neuroscience & Therapeutics
|May 13, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Altered Functional Specialization and Interhemispheric Coordination in Rhegmatogenous Retinal Detachment: Associations With Gene Expression, Neurotransmitter Receptor Distribution, and SVM-SHAP Classification

CNS neuroscience & therapeutics·2026
Same author

Analyzing the topological properties of resting-state brain function network connectivity based on graph theoretical methods in patients with high myopia.

BMC ophthalmology·2024
Same author

Immune function of peripheral T cells in patients with venous thromboembolism or coronary artery atherosclerosis.

Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology·2014
Same author

A critical role for ZDHHC2 in metastasis and recurrence in human hepatocellular carcinoma.

BioMed research international·2014
Same author

Chloride intracellular channel 1 participates in migration and invasion of hepatocellular carcinoma by targeting maspin.

Journal of gastroenterology and hepatology·2014
Same author

Locking laser frequency of up to 40  GHz offset to a reference with a 10  GHz electro-optic modulator.

Optics letters·2014

Rhegmatogenous retinal detachment (RRD) is linked to brain changes, including altered gray matter volume and neural timescales. These findings suggest coordinated structural and functional brain alterations in RRD patients.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Genetics

Background:

  • Neuroimaging reveals brain alterations in rhegmatogenous retinal detachment (RRD).
  • The molecular and neurochemical underpinnings of these macroscale brain changes in RRD remain unclear.
  • Understanding these correlates is crucial for elucidating RRD's impact on the brain.

Purpose of the Study:

  • To investigate gray matter volume (GMV), intrinsic neural timescale (INT), and structural covariance network (SCN) gradients in RRD patients.
  • To evaluate the potential causal effect of RRD genetic liability on brain structure using Mendelian randomization (MR).
  • To explore the relationship between SCN gradient alterations and gene expression patterns and neurotransmitter maps.

Main Methods:

  • Compared GMV, INT, and SCN gradients in 51 RRD patients and 45 healthy controls (HCs).
Keywords:
Mendelian randomizationimaging transcriptomicsintrinsic neural timescaleneurotransmitter density mapsrhegmatogenous retinal detachmentstructural covariance network gradient

More Related Videos

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function
09:09

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Published on: August 7, 2019

Related Experiment Videos

Last Updated: May 14, 2026

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
11:38

In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice

Published on: July 22, 2014

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function
09:09

Electrophysiological Investigations of Retinogeniculate and Corticogeniculate Synapse Function

Published on: August 7, 2019

  • Utilized two-sample MR to assess RRD genetic liability's causal effect on GMV.
  • Performed exploratory spatial association analyses with the Allen Human Brain Atlas (AHBA) and neurotransmitter maps.
  • Employed SHAP-explainable machine-learning models to compare structural and functional feature discrimination.

    • Main Results:

    • RRD patients exhibited reduced GMV in the visual network (VN) and shortened INT in the default mode network (DMN).
    • MR results supported a putative causal effect of RRD genetic liability on VN atrophy.
    • SCN gradients showed a hierarchical shift, and alterations spatially correlated with neurodevelopmental/synaptic gene expression and neurotransmitter maps.
    • INT-based machine learning models outperformed GMV-based models for classification (AUC=0.753).

    Conclusions:

    • Rhegmatogenous retinal detachment is associated with coordinated structural and functional alterations across cortical hierarchies.
    • Exploratory transcriptomic and neurotransmitter analyses offer biological context for observed brain abnormalities.
    • These findings may guide future research on RRD prognosis and underlying mechanisms.