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Candida Pneumonia with Lung Abscess as a Complication of Severe COVID-19 Pneumonia
Adel Abdelhadi1, Abeer Kassem2
1Department of Critical Care Medicine, Saqr Hospital, MOH, Ras Al-Khaimah, Ras Al-Khaimah, United Arab Emirates.
Abstract:
A South Asian male patient in his mid-forties presented with symptoms of severe 2019-nCoV (COVID-19) and recent brain infarction. Subsequently, he was found to have evidence of sepsis, underlying undetected diabetes mellitus (DM) and oral candida mucositis, possibly leading to the rare occurrence of direct spread to the lung, manifesting as a necrotizing candida lung abscess. We describe the diagnosis, clinical course, and management of the unique complication in this case that occurred during his admission, hospitalization, and eventual successful discharge from the hospital. This case highlights the importance of early identification and treatment of suspected COVID-19 infection based on clinical and radiological assessments before the confirmation of COVID-19 by real-time polymerase chain reaction (rtPCR) test result, especially in patients with hyperglycemia. It also indicates the complications that can occur due to COVID-19 such as arteriovenous manifestations and the rare occurrence of pulmonary candida lung abscess. Early detection and prompt management by interdisciplinary teams in the emergency room, followed by close monitoring of complications in the intensive care unit (ICU), can lead to successful outcomes in severe/critical COVID-19 infection.
Insights
This case study details a severe COVID-19 infection complicated by a rare pulmonary candida lung abscess in a patient with undiagnosed diabetes. Early recognition and multidisciplinary care led to successful recovery.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Pulmonology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, or COVID-19, can present with diverse clinical manifestations.
- Undiagnosed diabetes mellitus (DM) and opportunistic infections pose significant risks in COVID-19 patients.
- Fungal lung abscesses are rare but serious complications, particularly in immunocompromised individuals.
Observation:
- A middle-aged South Asian male with severe COVID-19 developed sepsis, hyperglycemia, and oral candidiasis.
- The patient experienced a brain infarction and subsequently developed a necrotizing pulmonary candida lung abscess.
- Clinical and radiological findings suggested COVID-19 prior to rtPCR confirmation.
Findings:
- The patient's hyperglycemia and oral candidiasis were linked to the rare direct spread of Candida to the lungs, forming an abscess.
- COVID-19 was associated with arteriovenous complications and this unique pulmonary fungal infection.
- Prompt diagnosis and management of hyperglycemia and fungal infection were crucial.
Implications:
- Early clinical and radiological assessment for COVID-19 is vital, especially in patients with hyperglycemia.
- Interdisciplinary management in the emergency room and intensive care unit (ICU) improves outcomes for severe COVID-19.
- This case underscores the potential for rare complications like pulmonary fungal abscesses in severe COVID-19 patients with metabolic derangements.
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