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Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
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Iron Deficiency Anaemia and Atonic Postpartum Haemorrhage Following Labour
Terence T Lao1, Lulu L Wong2, Shuk Yi Annie Hui2
1Department of Obstetrics & Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, 1/F, Block E, Shatin, Hong Kong, People's Republic of China. lao-tt@cuhk.edu.hk.
Reproductive Sciences (Thousand Oaks, Calif.)
|January 7, 2022
Summary
Iron deficiency anaemia (IDA) is linked to a higher risk of atonic postpartum haemorrhage (PPH). Addressing IDA may be crucial in reducing PPH rates.
Area of Science:
- Obstetrics and Gynecology
- Hematology
Background:
- Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality globally.
- Iron deficiency anaemia (IDA) is a common condition in pregnant women, but its association with atonic PPH is not fully understood.
Purpose of the Study:
- To investigate the association between iron deficiency anaemia (IDA) and the incidence of atonic postpartum haemorrhage (PPH) in women following labor.
Main Methods:
- Retrospective cohort study of women delivering after 24 weeks gestation from 1997 to 2019.
- IDA defined by hemoglobin <10 g/dL and serum ferritin <15 μg/L.
- Comparison of maternal characteristics and PPH incidence between women with and without IDA, with multivariate analysis.
Main Results:
- Women with IDA (0.86% of the cohort) had a significantly higher incidence of total PPH (4.5% vs 3.2%) and atonic PPH (3.1% vs 2.0%).
- IDA was independently associated with increased risk of total PPH (aRR: 1.455) and atonic PPH (aRR: 1.588) after adjusting for confounding factors.
- These associations persisted despite similar rates of labor interventions between groups.
Conclusions:
- Iron deficiency anaemia is an independent risk factor for atonic postpartum haemorrhage.
- Correction and prevention of IDA may be a key strategy to mitigate the rising incidence of atonic PPH.
- Potential mechanisms include placental adaptive changes in response to IDA.
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