Visual Disturbances in a Grave's Disease Patient After Sleeve Gastrectomy

Wernicke encephalopathy (WE) is a neuropsychiatric disorder that results from untreated severe thiamine deficiency, frequently described as a triad of ophthalmoplegia, ataxia, and confusion. While this triad is commonly used to describe WE, all three symptoms are observed in less than 20 percent of individuals with this diagnosis. Most commonly, WE is observed in individuals with significant alcohol use and associated malnutrition resulting in thiamine deficiency. However, this condition can also be diagnosed in patients with other sources of malnutrition, and less frequently in hypermetabolic states such as those with hyperthyroidism. Due to its broad clinical presentation and numerous causes, Wernicke encephalopathy can be difficult to diagnose. Diagnosis of WE guides management, as glucose before IV thiamine administration can be detrimental. Therefore, it is essential to understand the complexities of WE. In this paper, we discuss a patient who presented to the emergency department complaining of central vision loss, change in color perception, tinnitus, and difficulty walking two months post gastric sleeve and a recently diagnosed and, possibly inadequately treated, hyperthyroidism. The combination of recent sleeve gastrectomy and hyperthyroidism likely led to thiamine malabsorption and hypermetabolism, resulting in WE.