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Visible-Light-Responsive Surface Molecularly Imprinted Polymer for Acyclovir through Chicken Skin Tissue
Lantao Liu1, Nan Li1, Meijun Chen1
1College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
ACS Applied Bio Materials
|January 8, 2022
Summary
This study introduces a novel visible-light-responsive polymer for acyclovir (ACV) drug delivery. The new material overcomes UV light limitations, enabling controlled drug release and uptake via visible light through tissues.
Area of Science:
- Polymer Chemistry
- Materials Science
- Biomedical Engineering
Background:
- Conventional azobenzene polymers are limited by UV phototoxicity in biomedical applications.
- Visible-light-responsive materials are needed to overcome these limitations.
Purpose of the Study:
- To develop a visible-light-responsive molecularly imprinted polymer (VSMIP) for acyclovir (ACV) drug delivery.
- To investigate the properties and performance of the VSMIP compared to nonimprinted polymers.
Main Methods:
- Synthesized a novel tetra-ortho-methoxy-substituted azobenzene monomer (ADDDM).
- Fabricated VSMIP on silica microspheres using ADDDM for ACV imprinting.
- Evaluated VSMIP performance for drug loading, specificity, release kinetics, and photoisomerization.
Main Results:
- VSMIP demonstrated superior drug loading, specificity, and release kinetics compared to VSNIP.
- Achieved high selectivity for ACV over competing antiviral drugs.
- Successfully demonstrated visible-light-triggered ACV release and uptake through chicken skin tissue.
Conclusions:
- The developed VSMIP offers a promising platform for visible-light-controlled drug delivery systems.
- This technology overcomes UV phototoxicity issues, expanding potential biomedical applications.
