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Related Concept Videos

Other Glycolytic Pathways01:24

Other Glycolytic Pathways

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The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
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Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
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Related Experiment Video

Updated: Oct 7, 2025

Mitochondrial Preparation from Microglia for Glycan Analysis
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Published on: May 30, 2025

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Microglial metabolic flexibility: emerging roles for lactate.

Katia Monsorno1, An Buckinx1, Rosa C Paolicelli1

  • 1Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Trends in Endocrinology and Metabolism: TEM
|January 8, 2022
PubMed
Summary

Microglia, the brain's immune cells, utilize lactate as a key fuel source, influencing their function. Understanding microglial lactate metabolism offers new therapeutic targets for brain diseases.

Keywords:
CNS diseaselactatemetabolismmicrogliasynaptic function

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Area of Science:

  • Neuroimmunology
  • Immunometabolism
  • Central Nervous System (CNS) research

Background:

  • Microglia are key immune cells in the CNS, vital for brain health and disease.
  • Immunometabolism studies reveal how cellular metabolism controls macrophage functions like phagocytosis and inflammation.
  • Microglial metabolic control remains poorly understood, particularly regarding lactate's role.

Purpose of the Study:

  • To explore the role of lactate as an energy source and functional modulator in microglia.
  • To investigate the implications of microglial lactate metabolism in brain physiology and pathology.
  • To identify potential therapeutic strategies targeting microglial lactate metabolism.

Main Methods:

  • Comparative analysis of microglial and peripheral macrophage metabolism.
  • Investigating lactate uptake and utilization by microglia.
  • Assessing the impact of lactate on microglial functions such as phagocytosis and inflammatory responses.

Main Results:

  • Lactate serves as a significant bioenergetic substrate for microglia.
  • Microglial lactate metabolism influences key cellular functions, including inflammatory responses.
  • Evidence suggests parallels between microglial and peripheral macrophage lactate metabolism.

Conclusions:

  • Lactate is a critical metabolite modulating microglial function and metabolism in the CNS.
  • Understanding microglial lactate metabolism is essential for comprehending brain health and disease.
  • Targeting microglial lactate metabolism presents a promising therapeutic avenue for neurological disorders.