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Synchronous Occurrence of Advanced Gastric Carcinoma with Retroperitoneal Liposarcoma: A Case Report
Hiroshi Kobayashi1, Riuko Ohashi2, Masuo Ujita3
1Department of Pathology, Tachikawa General Hospital, Nagaoka, Niigata, Japan.
The American Journal of Case Reports
|January 8, 2022
Summary
This case report details a rare synchronous occurrence of gastric carcinoma and dedifferentiated liposarcoma. These synchronous tumors present significant diagnostic and staging challenges, highlighting the need for careful evaluation.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Gastric carcinoma (GC) is a leading cause of cancer death globally.
- Liposarcoma (LPS) is the most common adult sarcoma.
- Synchronous or metachronous occurrence of GC and LPS is exceptionally rare.
Observation:
- A man in his 70s presented with anorexia and weight loss.
- Gastroscopy revealed a Borrmann type 3 gastric tumor (adenocarcinoma).
- A large retroperitoneal tumor was initially staged as IVb.
Findings:
- The retroperitoneal tumor rapidly enlarged despite chemotherapy for GC.
- Biopsy revealed undifferentiated sarcoma, later revised to dedifferentiated LPS.
- Autopsy confirmed synchronous GC and dedifferentiated LPS, both MDM2 and CDK4 positive.
Implications:
- This is the first reported case of synchronous GC and LPS in English and Japanese literature.
- Synchronous GC and LPS pose complex diagnostic, staging, and treatment challenges.
- Accurate diagnosis and staging are critical for managing these rare co-occurring malignancies.
