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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Cardiac geometry, function and mechanics in left ventricular non-compaction cardiomyopathy with preserved ejection
Sarah A Guigui1, Sofia A Horvath1, Ivan A Arenas1
1Echocardiography Laboratory, Columbia University Division of Cardiology, Mount Sinai Heart Institute, 4300 Alton Road, De Hirsch Meyer Tower Suite 2070, Miami Beach, FL, 33140, USA.
Journal of Echocardiography
|January 8, 2022
Summary
Left ventricular non-compaction (LVNC) with preserved ejection fraction (EF) shows abnormal heart geometry and reduced longitudinal mechanics. This suggests increased myocardial stiffness in affected adults.
Area of Science:
- Cardiology
- Cardiovascular Imaging
- Cardiac Mechanics
Background:
- Left ventricular non-compaction (LVNC) cardiomyopathy is often associated with reduced ejection fraction (EF) and dilated cardiomyopathy.
- Data on LVNC presenting with preserved EF in adults is limited.
- This study focuses on characterizing cardiac geometry and mechanics in LVNC patients with preserved EF.
Purpose of the Study:
- To evaluate cardiac geometry and mechanics in adult patients diagnosed with LVNC and preserved EF.
- To compare these parameters with a control group without LVNC.
Main Methods:
- Retrospective cohort study of 17 LVNC patients with preserved EF (2008-2019).
- LVNC diagnosis based on transthoracic 2D echocardiographic criteria.
- Matched 1:1 with controls without LVNC.
- Analysis of geometric, functional, and mechanical parameters using 2D and speckle-tracking echocardiography.
Main Results:
- LVNC patients had similar LV systolic function and chamber dimensions but increased mass and relative wall thickness compared to controls.
- Abnormal LV geometry was more prevalent in LVNC patients (76% vs. 18%).
- Significantly decreased global longitudinal strain and increased rigid body rotation were observed in the LVNC group.
Conclusions:
- LVNC with preserved EF is characterized by impaired LV geometry and longitudinal mechanics.
- Increased myocardial stiffness, indicated by rigid body rotation, is a feature of this condition.
- These findings differentiate LVNC with preserved EF from typical presentations.
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