Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities

Area of Science:

• Medicinal Chemistry
• Organic Synthesis
• Heterocyclic Chemistry

Background:

• Quinoxalinones are heterocyclic compounds with significant interest in organic synthesis and medicinal chemistry.
• Recent years have seen advancements in synthetic strategies for functionalizing quinoxalinone scaffolds.
• However, comprehensive reports on the medicinal chemistry and pharmacological activities of quinoxalinones are limited.

Purpose of the Study:

• To review the applications of multifunctional quinoxalinones as privileged structures in medicinal chemistry.
• To highlight the diverse biological activities associated with quinoxalinone derivatives.
• To encourage further research and development of quinoxalinone-based therapeutics.

Main Methods:

• Literature review of synthetic strategies for quinoxalinones.
• Compilation and analysis of reported pharmacological activities of quinoxalinone derivatives.
• Categorization of biological activities based on existing studies.

Main Results:

• Quinoxalinones exhibit a wide spectrum of biological activities.
• These activities include anticancer, neuroprotective, antibacterial, antiviral, antiparasitic, anti-inflammatory, antiallergic, anti-cardiovascular, anti-diabetes, and antioxidant properties.
• The review consolidates evidence for quinoxalinones as privileged scaffolds in drug discovery.

Conclusions:

• Multifunctional quinoxalinones represent a valuable class of compounds for medicinal chemistry.
• Their diverse pharmacological profiles underscore their potential as therapeutic agents.
• This review provides a foundation for the rational design of novel quinoxalinone derivatives with enhanced medicinal applications.