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The novel HLA-DRB1*13:306 allele, identified by sequencing-based typing in a Chinese individual

Fang He1, Zhong-Zheng Zheng2, Lin An2

  • 1Department of Hematology, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, China.

HLA
|January 9, 2022
PubMed

Keywords:
HLA-DRB1*13:306novel allelesequencing-based typing

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Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...