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Diagnostic protocols and newer treatment modalities for cluster headache
Sakshi Prasad1, Abdulrahim Mehadi2, Nirja Kaka3
1Faculty of Medicine National Pirogov Memorial Medical University, 21018, Vinnytsya, Ukraine.
Disease-A-Month : DM
|January 10, 2022
Summary
Cluster headaches are severe primary headaches with significant quality of life impacts. This review covers their pathophysiology, risk factors, and diverse treatment options, highlighting the need for new interventions.
Area of Science:
- Neurology
- Headache Medicine
Background:
- Cluster headaches represent a severe primary headache syndrome with a substantial impact on patient quality of life.
- This multifactorial condition presents in episodic and chronic forms, influenced by genetics, lifestyle, and environmental factors.
Purpose of the Study:
- To provide a comprehensive overview of cluster headaches.
- To explore the pathophysiology, risk factors, differential diagnoses, and current treatment modalities for cluster headaches.
Main Methods:
- An extensive literature search was performed across Medline, Cochrane, Embase, and Google Scholar up to October 2021.
- Keywords included "Cluster Headache," "Triptans," "Neuromodulation," and "Migraine," utilizing relevant Medical Subject Headings (MeSH) terms.
Main Results:
- The review examined the epidemiology, pathophysiology, genetic underpinnings, and variants (episodic and chronic) of cluster headaches.
- Current literature reveals a broad spectrum of both preventive and abortive treatment options.
Conclusions:
- Despite existing therapeutic options for cluster headaches, there is an ongoing need for the development and integration of novel pharmacological and non-pharmacological interventions into clinical practice.
- Further research into newer, more effective treatments is essential for improving patient outcomes.
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