Related Experiment Video

Updated: Oct 7, 2025

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

17.8K

White-coat hypertension/effect is associated with higher arterial stiffness and stroke events

Alec Saunders1, Gani N Nuredini1, Frances A Kirkham2

  • 1Department of Medicine, Brighton and Sussex Medical School.

Journal of Hypertension
|January 10, 2022
PubMed

Insights

White-coat hypertension/effect (WCH/E) is linked to increased cardiovascular risk markers and a higher prevalence of lacunar stroke in patients with transient ischemic attack or stroke. This suggests WCH/E may indicate adverse cardiovascular outcomes.

Area of Science:

  • Cardiology
  • Neurology
  • Hypertension Research

Background:

  • The cardiovascular risk profile associated with white-coat hypertension/effect (WCH/E) is not fully understood.
  • WCH/E is characterized by elevated clinic blood pressure readings with normal ambulatory blood pressure.
  • Understanding WCH/E's impact is crucial for managing patients with cerebrovascular events.

Purpose of the Study:

  • To investigate the relationship between WCH/E and cardiovascular risk markers.
  • To determine the association between WCH/E and cerebrovascular events, specifically lacunar stroke and transient ischemic attack.
  • To clarify the clinical significance of WCH/E in patients with recent stroke or TIA.

Main Methods:

  • Sub-group analysis of the Arterial Stiffness In lacunar Stroke and Transient ischemic attack (ASIST) study.
  • Inclusion of patients aged ≥40 years with recent lacunar stroke or TIA.
  • Comparison of patients with WCH/E (clinic BP ≥140/90 mmHg, ambulatory BP <135/85 mmHg) versus those with target blood pressure (clinic BP <140/90 mmHg, ambulatory BP <135/85 mmHg).

Main Results:

  • Patients with WCH/E were older with higher BMI, central systolic and diastolic blood pressure, and arterial stiffness (measured by pulse wave velocity and cardio-ankle vascular index).
  • WCH/E showed an independent association with increased arterial stiffness.
  • Lacunar strokes were more prevalent in the WCH/E group, with individuals being significantly more likely to have had a lacunar stroke than a transient ischemic attack.

Conclusions:

  • In patients with lacunar stroke and TIA, WCH/E is associated with elevated cardiovascular risk markers.
  • WCH/E is linked to a higher prevalence of lacunar stroke.
  • These findings suggest that WCH/E represents an adverse cardiovascular risk profile in this patient cohort.
Abstract

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K
Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.2K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
72
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
139
Special considerations while measuring blood pressure01:28

Special considerations while measuring blood pressure

When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
858
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
938
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
131
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
79