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Related Experiment Video

Updated: Oct 7, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

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Active pulmonary tuberculosis: something old, something new, something borrowed, something blue.

Maria T A Wetscherek^1,2, Timothy J Sadler³, Janice Y J Lee³

¹Department of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Rd, Cambridge, CB2 0QQ, UK. maria.wetscherek@addenbrookes.nhs.uk.

Insights Into Imaging

|January 10, 2022

Summary

Radiology is vital for diagnosing and managing pulmonary tuberculosis (PTB). This review enhances understanding of PTB imaging, including classic and novel signs, aiding diagnosis and treatment decisions.

Keywords:

Computed tomography Imaging Immunocompromised Pulmonary tuberculosis X-ray

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Area of Science:

Radiology
Pulmonology
Infectious Diseases

Background:

Tuberculosis (TB) is a significant global health concern.
Radiology is essential for diagnosing and managing pulmonary tuberculosis (PTB).

Purpose of the Study:

To improve the understanding and diagnostic utility of imaging in PTB.
To review established and novel imaging findings in PTB.

Main Methods:

Review of established and emerging imaging findings in PTB.
Focus on imaging in immunocompromised individuals.
Illustration of PTB signs adapted from other diseases.

Main Results:

Detailed description of primary and post-primary TB imaging findings.
Inclusion of dissemination patterns: tree-in-bud, miliary nodules, lymphatic.
Highlighting specific signs: reversed halo, galaxy, and cluster signs.
Correlation of radiological signs with sputum smear results.

Conclusions:

Radiological signs are crucial for PTB diagnosis and management.
Awareness of specific signs aids in guiding isolation and empirical therapy decisions.
Imaging findings are particularly important in immunocompromised patients.