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Published on: December 18, 2016
Associations Between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study
Michelle C Johansen1, Wendy Wang2, Michael J Zhang3
1Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abstract:
The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (> 1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.

